Glucose Regulates Proinsulin and Prosomatostatin But Not Proglucagon Messenger Ribonucleic Acid Levels in Rat Pancreatic Islets1

Autor:	Beate Ritz-Laser, Paolo Meda, Alain Ktorza, Christophe Magnan, Eric Dumonteil, Jacques Philippe
Rok vydání:	2000
Předmět:	endocrine system medicine.medical_specialty Arginine Chemistry Insulin medicine.medical_treatment Glucagon secretion Proglucagon Glucagon Endocrinology Somatostatin Biochemistry Internal medicine medicine Glucose homeostasis hormones hormone substitutes and hormone antagonists Proinsulin
Zdroj:	Endocrinology. 141:174-180
ISSN:	1945-7170 0013-7227
DOI:	10.1210/endo.141.1.7230
Popis:	Insulin and glucagon are the major hormones involved in the control of fuel metabolism and particularly of glucose homeostasis; in turn, nutrients tightly regulate insulin and glucagon secretion from the islets of Langerhans. Nutrients have clearly been shown to affect insulin secretion, as well as insulin biosynthesis and proinsulin gene expression; by contrast, the effects of nutrients on proglucagon gene expression have not been studied. We have investigated the effect of glucose, arginine, and palmitate on glucagon release, glucagon cell content, and proglucagon messenger RNA (mRNA) levels from isolated rat islets in 24-h incubations. We report here that concentrations of glucose that clearly regulate insulin and somatostatin release as well as proinsulin and prosomatostatin mRNA levels, do not significantly affect glucagon release, glucagon cell content or proglucagon mRNA levels. In addition, though both 10 mm arginine and 1 mm palmitate strongly stimulated glucagon release, they did not affect prog...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::61c2c3c25896ab54fcb4143a4a515eda https://doi.org/10.1210/endo.141.1.7230 Zobrazit plný text záznamu