Calcium ion uptake by cultures of skin fibroblasts from normal subjects and from patients with systemic connective tissue disorders
| Autor: | A. F. Panasyuk, M. D. Grozdova, I. L. Sharlova |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
medicine.medical_specialty
integumentary system business.industry Connective tissue chemistry.chemical_element General Medicine Calcium Systemic scleroderma medicine.disease Calcium uptake General Biochemistry Genetics and Molecular Biology Scleroderma Endocrinology medicine.anatomical_structure chemistry Internal medicine medicine Rheumatic fever Calcium ion uptake skin and connective tissue diseases business Fibroblast |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 85:300-303 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/bf00801340 |
| Popis: | The uptake of radioactive calcium (45Ca) and the effect of adrenalin on this process were studied in suspensions of fibroblasts from monolayer cultures of skin fibroblasts from healthy persons and from patients with systemic scleroderma and rheumatic fever. A considerable increase in calcium uptake was found in systemic scleroderma compared with normal and with rheumatic fever. Adrenalin, in concentrations of 2·10−7–2·10−5 M, increased the rate of calcium accumulation by normal fibroblasts but had the opposite action in scleroderma. The results point to a disturbance of the function of the fibroblast membrane in systemic scleroderma, and this may lie at the basis of changes in the metabolic activity of these cells. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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