Renoprotective effect of Corallocarpus epigaea in Nephropathy in Wistar Rats
| Autor: | Awais Panjwani, Mohd. Bashar Momin, Amruta V. Yadav |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Creatinine
biology business.industry Vitamin E medicine.medical_treatment Albumin Serum albumin Renal function Pharmacology Malondialdehyde Nephrotoxicity Superoxide dismutase chemistry.chemical_compound chemistry medicine biology.protein Pharmacology (medical) business Pharmacology Toxicology and Pharmaceutics (miscellaneous) |
| Zdroj: | Research Journal of Pharmacy and Technology. 13:3163 |
| ISSN: | 0974-360X 0974-3618 |
| DOI: | 10.5958/0974-360x.2020.00559.4 |
| Popis: | The renoprotective effect of standardized hydroalcoholic extract of Corallocarpus epigaea was evaluated against cisplatin induced nephrotoxicity. The evaluation was performed on 36 Male Wistar rats. The acute toxicity study was performed in accordance with OECD 425 guidelines. Considering the safety of the extract the screening was done at three dose levels of 100, 200, 400mg/kg. The study was carried for period of 15 days. Vitamin E (100mg/kg) was used as a Standard nephroprotective agent. The kidney function test like serum uric acid, creatinine, albumin, (BUN) was performed. Oxidative stress studies like superoxide dismutase, malondialdehyde activity along with histopathological examination of kidneys was also conducted. Serum creatinine and Urea were elevated in Cisplatin treated group. Decrease in serum albumin was noted in cisplatin control as compared to normal control. Corallocarpus epigaea (100, 200, 400mg/kg) and Vitamin E (100mg/kg) decreased the serum creatinine and BUN and increased the serum albumin level. Decrease in activity of superoxide dismutase was observed in the Cisplatin group as compared to control. Corallocarpus epigaea (100, 200, 400mg/kg) and Vitamin E (100mg/kg) increased superoxide dismutase levels and decreased malondialdehyde levels as compared to Cisplatin group. Histopathological examination of the kidneys revealed the amelioration of Cisplatin induced renal tubular necrosis. Dose dependant increase in the activity was observed. Present investigation revealed that Corallocarpus epigaea resulted in attenuation of Cisplatin induced renal damage in rats. |
| Databáze: | OpenAIRE |
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