The Effects of Cocaine on Depressed Patients

Autor:	Frederick K. Goodwin, Joel Kotin, Robert M. Post
Rok vydání:	1974
Předmět:	Tearfulness Rapid eye movement sleep Vital signs Context (language use) Affect (psychology) Dysphoria Psychiatry and Mental health Blood pressure Anesthesia medicine Antidepressant sense organs medicine.symptom Psychology
Zdroj:	American Journal of Psychiatry. 131:511-517
ISSN:	1535-7228 0002-953X
DOI:	10.1176/ajp.131.5.511
Popis:	Cocaine, administered orally to patients with endogenous depressive illness, did not consistently affect vital signs or depressive symptomatology, but it did decrease rapid eye movement sleep and total sleep time. When administered intravenously in the context of a therapeutic interview, cocaine caused large, rapid increases in pulse and blood pressure concomitant with profound mobilization of affect and tearfulness. Infusions that caused lesser changes in vital signs were associated with milder degrees of affective change and less dysphoria. Thus, while cocaine was capable of eliciting positive affective change (such as calmness and elation) in depressed patients, affective flooding and dysphoric components were often admixed, indicating that cocaine's effect in this context could not be classified simply as antidepressant.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::61b9cac37a5dd98081a0e5dbb771fded https://doi.org/10.1176/ajp.131.5.511 Zobrazit plný text záznamu