Geldanamycin-Induced Morphological Changes Require Candida albicans Hyphal Growth Regulatory Machinery
| Autor: | Ian A. Cleary, Stephen P. Saville |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Hyphal growth Hypha biology Veterinary (miscellaneous) fungi 030106 microbiology Regulator Geldanamycin biology.organism_classification Applied Microbiology and Biotechnology Microbiology Hsp90 Yeast Cell biology 030207 dermatology & venereal diseases 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine chemistry Chaperone (protein) polycyclic compounds biology.protein Candida albicans Agronomy and Crop Science |
| Zdroj: | Mycopathologia. 186:103-107 |
| ISSN: | 1573-0832 0301-486X |
| DOI: | 10.1007/s11046-020-00511-3 |
| Popis: | In Candida albicans, geldanamycin treatment inhibits the essential chaperone Hsp90 and induces a change from yeast to filamentous morphology, likely by impeding cell cycle progression and division. However, filaments formed by wild-type cells upon geldanamycin exposure are quite different in appearance from true hyphae. We have observed that effects on morphology caused by geldanamycin treatment appear to vary in strains with defects in different morphological regulators. These results indicate that the filamentous forms induced by inhibiting Hsp90p, while not true hyphae, nonetheless require some components of the hypha induction machinery for their formation. Furthermore, we have found that BRG1, a known regulator of hypha formation, is also required for pseudohypha induction in response to nitrogen starvation and for the formation of elongated filaments upon exposure to geldanamycin. |
| Databáze: | OpenAIRE |
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