Oxidative Stress Responses of a Freshwater Teleost, Anabas testudineus, to an Endocrine Disruptor, Bisphenol A
| Autor: | R. N. Binitha, S. R. Soorya, C. Aruna Devi, Francis Sunny, B. V. Amrutha |
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| Rok vydání: | 2015 |
| Předmět: |
chemistry.chemical_classification
endocrine system medicine.medical_specialty Reactive oxygen species biology Glutathione peroxidase Anabas testudineus Glutathione biology.organism_classification medicine.disease_cause Toxicology Superoxide dismutase chemistry.chemical_compound Endocrinology chemistry Endocrine disruptor Catalase Internal medicine medicine biology.protein hormones hormone substitutes and hormone antagonists Oxidative stress |
| Zdroj: | Journal of Endocrinology & Reproduction. 19:7 |
| ISSN: | 2455-1244 0971-913X |
| DOI: | 10.18519/jer/2015/v19/86045 |
| Popis: | Bisphenol-A (BPA), an industrial chemical used to manufacture polycarbonate plastic, is considered as a potent estrogenic endocrine disruptor. A majority of xenobiotics exert their toxic effect by causing generation of reactive oxygen species, leading to oxidative stress. Reports regarding oxidative stress responses to BPA in fish are scanty. From this viewpoint, in the present study, a freshwater fish, Anabas testudineus , was exposed to sub-lethal concentrations of BPA (2.5, 5.0,&7.5 mg/l), for different time periods (7, 15&30 days). Four major enzymes of the fish's antioxidant defense system viz., catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (Se-GPx), and glutathione-S-transferase (GST), and the non-enzymatic antioxidant glutathione (GSH) were chosen as biomarkers to examine the effects of BPA. The activities of SOD, GPx and GSH were elevated to significant levels, while CAT and GST activities were decreased significantly suggesting oxidative stress in BPAexposed fish. Reactive oxygen species are known to cause DNA fragmentation. Hence, DNA fragmentation assay was also done. The severity of DNA fragmentation in fish exposed to 7.5 mg/L BPA (30days) was remarkably increased (p |
| Databáze: | OpenAIRE |
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