Nomogram predicting extrahepatic metastasis of hepatocellular carcinoma based on commonly available clinical data
| Autor: | Yu-Jr Lin, Sen-Yung Hsieh, Ya-Ting Cheng, Chen-Chun Lin, Chern-Horng Lee, Chee-Jen Chang, Chien-Heng Shen, Cho-Li Yen |
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| Rok vydání: | 2018 |
| Předmět: |
Oncology
medicine.medical_specialty Hepatology Proportional hazards model business.industry Concordance Hazard ratio Gastroenterology Individualized treatment Nomogram medicine.disease Confidence interval 03 medical and health sciences 0302 clinical medicine 030220 oncology & carcinogenesis Hepatocellular carcinoma Internal medicine medicine Extrahepatic metastasis 030211 gastroenterology & hepatology business |
| Zdroj: | JGH Open. 3:38-45 |
| ISSN: | 2397-9070 |
| Popis: | Background and Aim Extrahepatic metastasis (EHM) of hepatocellular carcinoma (HCC) leads to a worse prognosis. We aimed to develop a nomogram based on noninvasive pretreatment clinical data to predict EHM of HCC sooner. Methods Three cohorts containing 1820, 479, and 988 HCC patients were enrolled from three hospitals in different regions in Taiwan and served as the training and validation cohorts. Pretreatment clinical data were analyzed by Cox regression modeling for independent risk factors of EHM. Results Platelet count ≥ 200 × 103/μL, serum alfa-fetoprotein ≥ 100 ng/dL, tumor size ≥ 3 cm, tumor number > 1, and macrovascular invasion were independent risk factors for EHM and were used to develop a nomogram. This nomogram had concordance indices of 0.733 (95% confidence interval [CI]: 0.688-0.778) and 0.739 (95% CI: 0.692-0.787) for the prediction of EHM during a 5-year follow-up duration in the training and validation cohorts, respectively. A nomogram score > 61 implied a high risk of EHM (hazard ratio [HR] = 3.83; 95% CI: 2.77-5.31, P |
| Databáze: | OpenAIRE |
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