Additive-free regio- and diastereoselective construction of fully-substituted isoxazolidines employing diazo compounds

Autor:	Kishor Mohanan, Ruchir Kant, Mohd Khalid Zaheer, Ekta Gupta
Rok vydání:	2019
Předmět:	Nitrosobenzene chemistry.chemical_compound chemistry 010405 organic chemistry Organic Chemistry Functional group Lactam Diazo 010402 general chemistry 01 natural sciences Combinatorial chemistry 0104 chemical sciences
Zdroj:	Organic Chemistry Frontiers. 6:1109-1113
ISSN:	2052-4129
DOI:	10.1039/c8qo01421c
Popis:	An efficient additive-free three-component reaction of trifluorodiazoethane, nitrosobenzene, and allenic esters has been uncovered. This protocol provides easy access to a variety of trifluoromethylated isoxazolidines with good functional group tolerance. Moreover, this methodology was found to be extendable to α-diazomethylphosphonate providing phosphonylated isoxazolidines. The utility of these products has been demonstrated by the expedient synthesis of trifluoromethylated lactam.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::61a785a072ef8da008ac360cb1b63334 https://doi.org/10.1039/c8qo01421c Zobrazit plný text záznamu