Abstract P002: Metabolomic credentialling of murine chemical carcinogenesis model of urothelial cancer
| Autor: | Neveen A. Said |
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| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Molecular Cancer Therapeutics. 20:P002-P002 |
| ISSN: | 1538-8514 1535-7163 |
| DOI: | 10.1158/1535-7163.targ-21-p002 |
| Popis: | Bladder cancer (BCa) is the most common malignancy of urinary system with increasing incidence and mortality and limited treatment options. Therefore, it is imperative to validate preclinical models that faithfully represent BCa cellular, molecular, and metabolic heterogeneity to develop new therapeutics. We performed metabolomic profiling of premalignant and non-muscle invasive bladder cancer (NMIBC) that ensued in chemical carcinogenesis N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) mouse model. We identified the enriched metabolic signatures that associate with premalignant and NMIBC. We found that enrichment of lipid metabolism is the forerunner of carcinogen-induced premalignant and NMIBC lesions. Cross-species analysis revealed the prognostic value of the enzymes associated with carcinogen-induced enriched metabolic in human disease. To date, this is the first study describing the global metabolomic profiles associated with early premalignant and NMIBC and provide evidence that these metabolomic signatures can be used for prognostication of human disease. Citation Format: Neveen A. Said. Metabolomic credentialling of murine chemical carcinogenesis model of urothelial cancer [abstract]. In: Proceedings of the AACR-NCI-EORTC Virtual International Conference on Molecular Targets and Cancer Therapeutics; 2021 Oct 7-10. Philadelphia (PA): AACR; Mol Cancer Ther 2021;20(12 Suppl):Abstract nr P002. |
| Databáze: | OpenAIRE |
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