The role of cyclo-oxygenase-1 in high-salt diet-induced microvascular dysfunction in humans

Autor: Ivan Mihaljević, Julian H. Lombard, Ana Cavka, Ivana Jukić, Ines Drenjančević, Shane A. Phillips, Bojan Jelaković, Vatroslav Šerić, Anita Ćosić
Rok vydání: 2015
Předmět:
Zdroj: The Journal of Physiology. 593:5313-5324
ISSN: 0022-3751
DOI: 10.1113/jp271631
Popis: Key points Recent studies have shown that some of the deleterious effects of a high-salt (HS) diet are independent of elevated blood pressure and are associated with impaired endothelial function. Increased generation of cyclo-oxygenase (COX-1 and COX-2)-derived vasoconstrictor factors and endothelial activation may contribute to impaired vascular relaxation during HS loading. The present study aimed to assess the regulation of microvascular reactivity and to clarify the role of COX-1 and COX-2 in normotensive subjects on a short-term HS diet. The present study demonstrates the important role of COX-1 derived vasoconstrictor metabolites in regulation of microvascular blood flow during a HS diet. These results help to explain how even short-term HS diets may impact upon microvascular reactivity without changes in blood pressure and suggest that a vasoconstrictor metabolite of COX-1 could play a role in this impaired tissue blood flow. Abstract The present study aimed to assess the effect of a 1-week high-salt (HS) diet on the role of cyclo-oxygenases (COX-1 and COX-2) and the vasoconstrictor prostaglandins, thromboxane A2 (TXA2) and prostaglandin F2α (PGF2α), on skin microcirculatory blood flow, as well as to detect its effect on markers of endothelial activation such as soluble cell adhesion molecules. Young women (n = 54) were assigned to either the HS diet group (N = 30) (∼14 g day–1 NaCl ) or low-salt (LS) diet group (N = 24) (
Databáze: OpenAIRE
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