Polymeric reagent synthesis of luteinizing hormone-releasing hormone

Autor:	Yitschak Koch, Miriam Rotman, Eli Hazum, Rami Kalir, Mati Fridkin
Rok vydání:	1977
Předmět:	chemistry.chemical_compound Chemistry Reagent Polystyrene Luteinizing hormone Applied Microbiology and Biotechnology Biochemistry Combinatorial chemistry Biotechnology Hormone
Zdroj:	Journal of Solid-Phase Biochemistry. 2:175-182
ISSN:	0146-0641
DOI:	10.1007/bf02991406
Popis:	Luteinizing hormone-releasing hormone, pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2,2 was synthesized in a stepwise manner by two approaches: the use of insoluble polymeric active esters derived from (4-hydroxy-3-nitro)benzylated polystyrene and that of solubleN,N-dicyclohexylcarbodiimide. The overall yields of the syntheses were 40 and 7%, respectively. The efficiencies of the two synthetic routes, in which identical intermediate peptides were prepared, are compared.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::618a96464ac53ece43f9c5e7db8400f4 https://doi.org/10.1007/bf02991406 Zobrazit plný text záznamu