Magnetic Epidermal Growth Factor Conjugate for Targeted Delivery to Grafted Tumor in Mouse Model
| Autor: | A. V. Petrov, A. V. Soloviev, Y. Marchenko, T. M. Zimina, T. A. Scharafutdinova, B. Nikolaev, A. V. Dobrodumov, V. V. Luchinin, L. Yakovleva |
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| Rok vydání: | 2013 |
| Předmět: |
Relaxometry
medicine.diagnostic_test Chemistry Magnetic resonance imaging Electronic Optical and Magnetic Materials chemistry.chemical_compound Nuclear magnetic resonance In vivo Epidermal growth factor Cancer cell medicine Magnetic nanoparticles Electrical and Electronic Engineering hormones hormone substitutes and hormone antagonists Conjugate Carbodiimide |
| Zdroj: | IEEE Transactions on Magnetics. 49:429-435 |
| ISSN: | 1941-0069 0018-9464 |
| DOI: | 10.1109/tmag.2012.2223203 |
| Popis: | Magnetic nanoparticles conjugated with epidermal growth factor (MNP-EGF conjugates) were investigated by magnetic resonance (MR) relaxometry, on-chip quasielastic light scattering and magnetophoresis in aqueous dispersions and by MR imaging in phantom and in vivo models. MNP-EGF conjugates were prepared by carbodiimide EGF bonding with NH2-dextran modified iron oxide MNPs. The coefficients of magnetic relaxation efficiency (R1,R2,R2*) of MNP-EGF conjugates appeared to be close to the values obtained for nonconjugated MNPs and are correlating with those characteristic for negative contrast agents for MR imaging. MNP-EGF conjugates demonstrated ability of targeting MNPs to EGF receptors in EGF-overexpressed tumors. The feasibility of the MNP-EGF conjugates in diagnostics of certain cancer types was studied by MR imaging using mouse tumor models. It has been shown that intravenous and subcutaneous administration of MNP-EGF conjugates provided an enhancement of MR imaging contrast at the areas of accumulated cancer cells in melanoma mice model. |
| Databáze: | OpenAIRE |
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