Pediatric Primary Pleural Synovial Sarcoma: A Unique Case Report with Brief Review of Literature

Autor:	Sharazad Saab, Agne Petrosiute, Ajay Gupta, Anant Vatsayan
Rok vydání:	2019
Předmět:	Pathology medicine.medical_specialty Oncogene business.industry Cancer predisposition Genetic variants medicine.disease Synovial sarcoma Unknown Significance Oncology Pediatrics Perinatology and Child Health Cystadenoma Medicine Ganglioneuroma business Pleural Synovial Sarcoma
Zdroj:	Indian Journal of Medical and Paediatric Oncology. 40:435-439
ISSN:	0975-2129 0971-5851
Popis:	Synovial sarcoma (SS) primary to the pleura is an extremely rare tumor. So far, only nine cases have been reported in pediatric patients. However, none of these patients was found to have a conglomeration of tumors. Here, we report a case of 16-year-old female with monophasic SS and synchronous occurrence of left paraspinal ganglioneuroma and a right paraovarian cystadenoma. A next-generation sequencing genetic panel revealed a novel variant of unknown significance in the MET gene. The occurrence of multiple different tumors in a young patient with a novel genetic variant in a known oncogene (MET) may suggest a possibility of a hitherto unknown cancer predisposition syndrome. We also present a brief review of primary pleural SS reported in pediatric patients.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::61816dce51455a102e91d56394f91f0c https://doi.org/10.4103/ijmpo.ijmpo_233_17 Zobrazit plný text záznamu Plný text ve formátu PDF