Antisense Phosphorothioate Oligodeoxyribonucleotide Targeted against ICAM-1: Use of I-Linker to Eliminate 3‘-Terminal Phosphorothioate Monoester Formation

Autor:	Vasulinga T. Ravikumar, R. Krishna Kumar, Claus Rentel, Daniel C. Capaldi, Brett Turney, Douglas L. Cole
Rok vydání:	2003
Předmět:	Solvent ICAM-1 chemistry.chemical_compound chemistry Stereochemistry Organic Chemistry Depurination Moiety Dichloroacetic acid Physical and Theoretical Chemistry Oligonucleotide synthesis Linker
Zdroj:	Organic Process Research & Development. 7:259-266
ISSN:	1520-586X 1083-6160
DOI:	10.1021/op020098x
Popis:	Detritylation of a 5‘-O-DMT-2‘-deoxyadenosine moiety attached to solid support under acidic conditions (3% dichloroacetic acid/solvent) leads to depurination during oligonucleotide synthesis. Depro...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::6175bd98e9db7dc4e8c2d09a6075a85d https://doi.org/10.1021/op020098x Zobrazit plný text záznamu