Serum Adiponectin, TNF-α, IL-6 and Insulin Resistance in Women with Polycystic Ovary Syndrome
| Autor: | Na young Jang, Kyung Ho Lim, Jung Hyun Noh, Soo Kyung Kwon, Chong Rae Cho, Soon Hee Lee, Young Ah Kim, Byoung Doo Rhee, Kyung Soo Ko, Jeong Hyun Park, Dong-Jun Kim, Tae Hyun Um |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
medicine.medical_specialty
endocrine system diseases biology Adiponectin business.industry Insulin medicine.medical_treatment nutritional and metabolic diseases Adipokine medicine.disease Polycystic ovary female genital diseases and pregnancy complications Endocrinology Sex hormone-binding globulin Insulin resistance Diabetes mellitus Internal medicine medicine biology.protein business Body mass index |
| Zdroj: | The Journal of Korean Diabetes Association. 30:104 |
| ISSN: | 1015-6461 |
| DOI: | 10.4093/jkda.2006.30.2.104 |
| Popis: | Abstract - Background: To determine plasma adipokines such as adiponectin, IL-6 and TNF-α concentrations in women with and without polycystic ovary syndr ome (PCOS) and to assess possible correlations of adipocytokines to the hormonal and metabolic parameters, including measures of insulin resistance (IR). Methods: Forty-four selected women were classified as follows: 13 obese (body mass index (BMI) ≥ 25 kg/m 2 ) with PCOS; 15 non-obese (BMI < 25 kg/m 2 ) with PCOS; 8 obese without PCOS, and 8 non-obese without PCOS. Blood samples were collecte d from all women with or without PCOS after an overnight fast. Serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), total testosterone, 17-α-hydroxyprogesterone, dehydroepiandrosterone sulfate (DHEA-S), sex hormone-binding globulin (SHBG), insulin, glucose, adiponectin, TNF-α and IL-6 were measured. Measures of IR included HOMA-IR and QUICKI. Results: In non-obese group, fasting insulin levels and HOMA-IR in PCOS were significantly higher compared to control. However, Adiponectin, TNF-α and IL-6 concentrations were found not to be different in obese women with PCOS as compared with obese women without PCOS and in non-obese women with PCOS as compared with non-obese women without PCOS. Adiponectin concentrations correlated inversely with BMI, waist circumference (WC), total fat ma ss, serum insulin, and HOMA-IR in PCOS group. However, multiple regression analysis showed that BMI was the only independent determinant of adiponectin concentration. Conclusion: Our results suggest that insulin sensitivity per se probably does not play any role in the control of adipokines levels such as adiponectin, TNF-α and IL-6 in PCOS women (J Kor Diabetes Assoc 30:104~111, 2006). ━━━━━━━━━━━━━━━━ ━━ |
| Databáze: | OpenAIRE |
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