Antihyperglycemic and renal protective activities of Anacardium occidentale (anacardiaceae) leaves in streptozotocin induced diabetic rats
| Autor: | Leonard Tedong, Théophile Dimo, Acha Emmanuel Asongalem, Pierre Kamtchouing, Dongmo Selestin Sokeng, Jean–François Flejou, Paul Désiré Djomeni Dzeufiet, Patrice Callard |
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| Rok vydání: | 2005 |
| Předmět: |
Glycosuria
medicine.medical_specialty Type 1 diabetes Kidney biology business.industry Anacardium Insulin medicine.medical_treatment biology.organism_classification medicine.disease Streptozotocin Nephrotoxicity Endocrinology medicine.anatomical_structure Complementary and alternative medicine Diabetes mellitus Internal medicine Drug Discovery medicine medicine.symptom business medicine.drug |
| Zdroj: | African Journal of Traditional, Complementary and Alternative Medicines. 3 |
| ISSN: | 0189-6016 |
| DOI: | 10.4314/ajtcam.v3i1.31136 |
| Popis: | Earlier studies from our laboratory have indicated hypoglycaemic action of Anacardium occidentale (AO) leaves in experimental type 1 diabetes. Streptozotocin-induced diabetes in rats had been shown to be associated with functional and/or morphological changes in the kidney. Therefore, in the present investigation, we carried out studies on streptozotocin (STZ)-induced type 1 diabetes in rats chronically treated with Anacardium occidentale on the functional and histological alterations of kidneys. Albino rats were divided into 7 groups (n = 5) receiving graded doses of hexane extract of Anacardium occidentale leaf by gavage, (150 and 300 mg/kg/day) and insulin (5 IU/kg). Renal ultrastructure was studied by measuring: diameter of Bowman’s capsule, distribution and total area occupied by glomerular capillaries, PAS positive structures. AO at the dose of 300 mg/kg/day, showed significant reduction (P < 0.05) of blood glucose level, total protein excreted, glycosuria and urea in diabetic rats. Anacardium treatment, initiated 3 days after diabetes induction, reduced destruction of renal structure and other metabolic disturbances more than when treatment was initiated two weeks after. Histopathological study showed that A. occidentale significantly reduced accumulation of mucopolysaccharides in the kidneys of diabetic animals. The extract of AO at the dose of 300 mg/kg had no nephrotoxic potential in normal rats. The present study demonstrates the efficacy of Anacardium occidentale (hexane extract) in reducing diabetes-induced functional and histological alterations in the kidneys. |
| Databáze: | OpenAIRE |
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