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Diabetes mellitus(DM) is a group of metabolic diseases characterized by a state of chronic hyperglycemia resulting from defect in insulin secretion, insulin action or both. Diabetes mellitus is characterized by an abnormal correlative deficiency of insulin and insulin resistance. Adenosine Deaminase (ADA) is an enzyme involved in purine metabolism.ADA is considered to be a good biomarker of cell mediated immunity.In the present case control pilot study, serum glucose and serum ADA levels were estimated in 20 patients with type 2 DM and compared the results with age and sex matched ten healthy controls. A statistically significant elevation of serum ADA was found in diabetic subjects when compared to controls.This indicates that serum ADA can be considered as a biomarker to diagnose diabetes in a population. |
