Hyperthyreose bei Schilddrüsenhormonbehandlung der Jodmangelstruma*
| Autor: | G. Klaushenke, D. Emrich |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
endocrine system
Wolff–Chaikoff effect Goiter endocrine system diseases business.industry Thyroid Physiology General Medicine medicine.disease Iodine deficiency medicine.anatomical_structure TRH stimulation test Thyroid Hormone Treatment Medicine In patient business hormones hormone substitutes and hormone antagonists Hormone |
| Zdroj: | DMW - Deutsche Medizinische Wochenschrift. 111:577-581 |
| ISSN: | 1439-4413 0012-0472 |
| DOI: | 10.1055/s-2008-1068492 |
| Popis: | Standardized assessment of 1973 patients with iodine-deficient goitre, treated on average with 100 micrograms thyroxin, revealed clinical signs of thyroid hyperfunction in 2.4%. But an increased hormone concentration alone was not sufficient for the diagnosis. Probable cause of hyperfunction was autonomy of the goitre, as indicated by a negative TRH test before treatment had begun. It was calculated that in this case the risk of hyperthyroidism from thyroid hormone administration was 10%, but only 0.7% in patients with a primarily positive TRH test. Hyperthyroid symptoms disappeared and hormone concentration became normal in 60% of patients after thyroid-hormone administration had been stopped. It is concluded that patients with primarily negative TRH test must be carefully monitored while receiving thyroid-hormone treatment. |
| Databáze: | OpenAIRE |
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