Synthesis of some benzoxazinyl pyrazolone arylidenes as potent antimicrobials and antioxidants

Autor:	George Sonia, Knolin K. Thachil, Manoj Kumar Parameswaran, Ravi Thengungal Kochupappy
Rok vydání:	2013
Předmět:	Antioxidant Chemistry medicine.medical_treatment Organic Chemistry Pyrazolone Carbon-13 NMR Pyrazole Hydrazide Antimicrobial chemistry.chemical_compound Proton NMR medicine Organic chemistry General Pharmacology Toxicology and Pharmaceutics Spectral data medicine.drug
Zdroj:	Medicinal Chemistry Research. 23:1320-1326
ISSN:	1554-8120 1054-2523
DOI:	10.1007/s00044-013-0719-9
Popis:	2-[2-(3-Methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)-2-oxoethyl]-2H-1,4-benzoxazin-3(4H)-one (3) was obtained starting from methyl-(3,4-dihydro-3-oxo-2H-1,4-benzoxazin-2-yl) acetate (1) through the corresponding hydrazide (2). Condensation of (3) with different aromatic aldehydes under Knoevengel condensation afforded 2-{2-[3-methyl-4-(2-methylbenzylidine)-5-oxo-4,5-dihydro-1H-pyrazol-1-yl]-2-oxoethyl}-2H-1,4-benzoxazin-3(4H)-ones (4a–k). The structures of the compounds were determined by FT-IR, 1H NMR, 13C NMR, mass spectral data, and elemental analysis. All the synthesized compounds were screened for their in vitro antimicrobial and antioxidant studies.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::61332c397c69877b6cbb923df328eb84 https://doi.org/10.1007/s00044-013-0719-9 Zobrazit plný text záznamu Full text from SpringerLink