Continuous manufacturing as an enabling tool with green credentials in early-phase pharmaceutical chemistry
| Autor: | Berthold Schenkel, Xiangguang Tian, Hongwei Yang, Like Chen, Benjamin Martin, Hansjoerg Lehmann, Jutta Polenk |
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| Rok vydání: | 2018 |
| Předmět: |
010405 organic chemistry
Computer science Continuous flow Process (engineering) Process Chemistry and Technology Scale (chemistry) Thermal safety Continuous manufacturing Management Monitoring Policy and Law Work in process 010402 general chemistry 01 natural sciences Medicinal chemistry Catalysis 0104 chemical sciences Chemistry (miscellaneous) Hazardous waste Early phase Waste Management and Disposal |
| Zdroj: | Current Opinion in Green and Sustainable Chemistry. 11:27-33 |
| ISSN: | 2452-2236 |
| Popis: | The paper outlines the application of continuous manufacturing to hazardous chemistries, with particular application to early-phase pharmaceutical chemistry. Three case studies are shared with a view to highlighting the factors which render continuous flow setups a suitable tool for minimizing risk within exothermic and unstable chemistries. In each case the evolution of the chemical process from gram scale in discovery chemistry to kilogram scale in process development is detailed, with emphasis on thermal safety and general health and safety considerations. Process intensification, risk reduction and improved yield are highlighted, supporting continuous manufacturing as an enabling tool in line with green principles. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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