Effects of ascorbate on monosodium glutamate-associated toxicities that may impact upon immunocompetence
| Autor: | VS Ekam, M. Obi-Abang, A.E. Abara, S.P. Malu, F.U Uboh, G.O. Obochi |
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| Rok vydání: | 2009 |
| Předmět: |
medicine.medical_specialty
Monosodium glutamate Health Toxicology and Mutagenesis Excitotoxicity medicine.disease_cause Ascorbic acid Pollution Lipid peroxidation chemistry.chemical_compound Blood serum Endocrinology chemistry Internal medicine Immunology Toxicity medicine Membrane fluidity Environmental Chemistry Oxidative stress |
| Zdroj: | Toxicological & Environmental Chemistry. 91:547-557 |
| ISSN: | 1029-0486 0277-2248 |
| Popis: | Excitotoxic food additives react with specialized receptors in the brain and other tissues. Unfortunately, in many instances, these reactions lead to free radical generation (resulting in oxidative stress/lipid peroxidation) and altered membrane fluidity. Ultimately, damage induced by these agents was shown to give rise to endocrine disorders and altered cell-mediated immune responses in general, and dysfunction of lymphocytes and macrophages in particular. The effects of ascorbate against some basic toxicities (that ultimately evolve into endocrine and immune system dysfunctions) induced by monosodium glutamate (MSG) was studied in rats. For 21 days, control rats received a daily placebo (4 mL distilled water) via gastric intubation; other rats were treated daily with 100 mg MSG kg−1 body weight or 100 mg MSG + 100 mg ascorbate kg−1 in 4 mL vehicle. A day after the final exposure, rats were euthanized. Serum was isolated to examine several lipid and electrolyte parameters, i.e. cholesterol, triglycerides... |
| Databáze: | OpenAIRE |
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