Utility of 4,6-dichloro-2-(methylthio)-5-nitropyrimidine. An efficient solid-phase synthesis of olomoucine

Autor:	Lars G.J. Hammarström, Sharada Shenvi Labadie, Nancy Elisabeth Krauss, David Bernard Smith, Francisco Xavier Talamas
Rok vydání:	2002
Předmět:	Solid-phase synthesis Chemistry Block (telecommunications) Organic Chemistry Drug Discovery Organic chemistry Biochemistry Combinatorial chemistry
Zdroj:	Tetrahedron Letters. 43:8071-8073
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(02)01953-6
Popis:	4,6-Dichloro-2-(methylthio)-5-nitropyrimidine has been utilized as a building block for an efficient nine-step synthesis of olomoucine. The methodology reported herein is applicable to the regiocontrolled solution and solid-phase synthesis of libraries of highly substituted purines, as well as other related scaffolds.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::6129c3b991d2ffeb57d6aea7650a8561 https://doi.org/10.1016/s0040-4039(02)01953-6 Zobrazit plný text záznamu Full Text from ScienceDirect