A DOUBLE-BLIND TRIAL OF LOW DOSES OF SUBCUTANEOUS HEPARIN IN THE PREVENTION OF DEEP-VEIN THROMBOSIS AFTER MYOCARDIAL INFARCTION*1
| Autor: | A.S. Douglas, G. Terry, A.G. Beattie, D. Ogston, Charles Warlow, A.C.F. Kenmure |
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| Rok vydání: | 1973 |
| Předmět: |
medicine.medical_specialty
medicine.diagnostic_test business.industry Deep vein General Medicine Heparin medicine.disease Fibrinogen Thrombophlebitis Thrombosis Pulmonary embolism medicine.anatomical_structure Internal medicine Cardiology Medicine Myocardial infarction business Electrocardiography medicine.drug |
| Zdroj: | The Lancet. 302:934-936 |
| ISSN: | 0140-6736 |
| DOI: | 10.1016/s0140-6736(73)92597-x |
| Popis: | A randomised double-blind trial was undertaken in a hundred and fortysix patients with acute myocardial infarction to determine whether low-dose subcutaneous heparin reduced the frequency of deep-venous thrombosis (D.V.T.) in the legs. Low-dose heparin (5000 units 12-hourly) started within 12 hours of the onset of myocardial infarction and continued for 10 days significantly reduced the frequency of D.V.T., diagnosed by the 125 I-fibrinogen technique, from 17·2% in the control group to 3·2% in the heparin-treated group. There were no complications of heparin treatment. Since the relation between the prevention of D.V.T., detected with 125 I-labelled fibrinogen, and the prevention of pulmonary embolism is uncertain, it would seem reasonable to embark on a larger trial to determine whether the frequency of pulmonary embolism could be reduced with low-dose heparin. |
| Databáze: | OpenAIRE |
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