ADHS und Alkoholabhängigkeit: Gemeinsame genetische Grundlagen?

Autor:	Norbert Wodarz, Rainer Laufkötter, Monika Johann, Kirsten Lange
Rok vydání:	2004
Předmět:	business.industry Significant difference Alcohol dependence medicine.disease behavioral disciplines and activities Genetic load Substance abuse Polymorphism (computer science) mental disorders Genetic predisposition Medicine Allele business Clinical psychology
Zdroj:	Psychiatrische Praxis. 31:111-113
ISSN:	1611-8340 1611-8332
DOI:	10.1055/s-2004-828449
Popis:	INTRODUCTION Nearly 50 % of subjects with continuing symptoms of attention-deficit hyperactivity disorder (ADHD) in adulthood show a comorbid substance use disorder. Both, ADHD and alcohol dependence have a high genetic load and might even share overlapping sources of genetic liability. METHOD We investigated phenotype and 5-HTT/5-HT2c allelic characteristics in 314 alcoholics of German descent. RESULT 21 % of the alcoholics fulfilled DSM-IV-criteria of ADHD with ongoing symptoms in adulthood. There was no significant difference in 5-HTT- or 5-HT2c-allele distribution between alcoholics and matched controls or between alcoholics with or without ADHD. CONCLUSION In our sample the functional relevant 5-HTT-promoter and the 5-HT2c-receptor Cys23Ser polymorphism do not contribute to the supposed common genetic predisposition of ADHD and alcohol dependence.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::6125d971d9b9b71ea3204dbb3df0fd65 https://doi.org/10.1055/s-2004-828449 Zobrazit plný text záznamu