Combined treatment with surgery and short duration oral antifungal therapy in patients with limited dermatophyte toenail infection

Autor:	E G V Evans, M J D Goodfield
Rok vydání:	2000
Předmět:	medicine.medical_specialty Nail Infection integumentary system Combination therapy business.industry Dermatology medicine.disease medicine.disease_cause Surgery medicine.anatomical_structure Pharmacotherapy Nail disease medicine Nail (anatomy) Dermatophyte Terbinafine business Mycosis medicine.drug
Zdroj:	Journal of Dermatological Treatment. 11:259-262
ISSN:	1471-1753 0954-6634
DOI:	10.1080/09546630050517207
Popis:	BACKGROUND: Localized nail infection with dermatophyte fungi occurs both as a primary presentation of fungal disease and as a pattern of failure of previous treatment, even with modern antifungal agents. METHODS: Twelve patients (six treatment failures and six previously untreated) were confirmed to have dermatophyte infection of their toenails, and were then treated with surgical removal of the affected area of nail, followed by 28 days of oral terbinafine (250 mg/day). RESULTS: Repeat mycology 12 months after the oral treatment confirmed mycological cure in all patients, and all treated nails were clinically normal. Histology of excised nail showed appearances compatible with a dermatophytoma. CONCLUSIONS: Combined modality treatment is successful and well tolerated for localized nail disease, and provides a useful means of dealing with treatment failure after conventional oral treatment as well as primary therapy of limited nail disease. (J Dermatol Treat (2000) 11: 259-262)
Databáze:	OpenAIRE
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