In Vivo CD4+ T Cell Differentiation and Function: Revisiting the Th1/Th2 Paradigm
| Autor: | Mikel Ruterbusch, Kurt B Pruner, Laila Shehata, Marion Pepper |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Effector medicine.medical_treatment T cell Immunology T-cell receptor Biology Cell biology 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Cytokine medicine.anatomical_structure In vivo 030220 oncology & carcinogenesis T cell differentiation medicine Immunology and Allergy Transcription factor Memory T cell |
| Zdroj: | Annual Review of Immunology. 38:705-725 |
| ISSN: | 1545-3278 0732-0582 |
| DOI: | 10.1146/annurev-immunol-103019-085803 |
| Popis: | The discovery of CD4+ T cell subset–defining master transcription factors and framing of the Th1/Th2 paradigm ignited the CD4+ T cell field. Advances in in vivo experimental systems, however, have revealed that more complex lineage-defining transcriptional networks direct CD4+ T cell differentiation in the lymphoid organs and tissues. This review focuses on the layers of fate decisions that inform CD4+ T cell differentiation in vivo. Cytokine production by antigen-presenting cells and other innate cells influences the CD4+ T cell effector program [e.g., T helper type 1 (Th1), Th2, Th17]. Signals downstream of the T cell receptor influence whether individual clones bearing hallmarks of this effector program become T follicular helper cells, supporting development of B cells expressing specific antibody isotypes, or T effector cells, which activate microbicidal innate cells in tissues. These bifurcated, parallel axes allow CD4+ T cells to augment their particular effector program and prevent disease. |
| Databáze: | OpenAIRE |
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