Evaluation of hepatoprotective and antioxidant activity of Ichnocarpus frutescens (Linn.) R.Br. on paracetamol-induced hepatotoxicity in rats
| Autor: | Pinaki Sengupta, Siva S Nayak, Tapan Kumar Maity, Deepak Kumar Dash, Bhim Chandra Maiti, Tirtha Ghosh, Veerendra C. Yeligar, D. Rajalingam |
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| Rok vydání: | 2007 |
| Předmět: |
Antioxidant
biology Chemistry medicine.medical_treatment Pharmaceutical Science Pharmacology biology.organism_classification Liver disorder Transaminase Lipid peroxidation Superoxide dismutase chemistry.chemical_compound Ichnocarpus frutescens Biochemistry Hepatoprotection medicine biology.protein Pharmacology (medical) Hepatoprotective Agent |
| Zdroj: | Tropical Journal of Pharmaceutical Research. 6 |
| ISSN: | 1596-9827 1596-5996 |
| DOI: | 10.4314/tjpr.v6i3.14656 |
| Popis: | Purpose: The entire plant including the flowers, of Ichnocarpus frutescens R.Br. (Apocynaceae) has been used for the treatment of cancer, skin infections, diabetes and liver disorder. The present study is aimed at evaluating the hepatoprotective effect of chloroform and methanol extract (CEIF and MEIF) of whole plant of I. frutescens (Linn.) by paracetamol-induced liver damage in rats. Methods: The chloroform and methanolic extracts of I. frutescens (CEIF and MEIF) were studied for their hepatoprotective and antioxidant effects on paracetamol (750mg/kg) induced acute liver damage on Wistar albino rats. The degree of protection was measured by using biochemical parameters such as serum glutamate oxalate transaminase (SGOT) and serum glutamate pyruvate transaminase (SGPT), alkaline phosphatase (ALP), bilirubin and total protein. Further, the effects of both extracts on lipid peroxidation (LPO), glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT) were estimated. Results: CEIF and MEIF at a dose level of 250mg/kg and 500mg/kg produce significant (P |
| Databáze: | OpenAIRE |
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