Role of Molecular Markers in Endometrial Cancer: Review
| Autor: | Santhosh Kuriakose |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Oncology
medicine.medical_specialty 030219 obstetrics & reproductive medicine business.industry Endometrial cancer Obstetrics and Gynecology medicine.disease Key features Lynch syndrome 03 medical and health sciences Therapeutic approach 0302 clinical medicine Molecular classification Surgical oncology 030220 oncology & carcinogenesis Internal medicine Risk stratification medicine Carcinoma business |
| Zdroj: | Indian Journal of Gynecologic Oncology. 17 |
| ISSN: | 2363-8400 2363-8397 |
| Popis: | Genomic studies have given insights into the heterogeneity of endometrial cancer based on its molecular alterations. The unravelling of a four-tier molecular classification of endometrial cancer, that is biologically different, has challenged clinicians to take up a therapeutic approach incorporating this vital information. Embracing this novel classification in a clinical setting is not always practical. This review looks into pragmatic methods to ascertain the molecular subtypes and how this can be incorporated into the traditional clinicopathological parameters. Integrated risk stratification will become an essential component of care in gynaecologic oncology. Molecular characterisation furthers accords an opportunity to identify and screen family members affected by Lynch syndrome. This review summarises the key features of the molecular subtype-based classification in endometrial carcinoma and the results published from various patient cohorts and also discusses the potential application of this information in a clinical setting that will result in delivering a more objective and individualised patient care. |
| Databáze: | OpenAIRE |
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