Flow-Injection Spectrophotometric Determination of Captopril Exploiting Silver Chloranilate Solid-Phase Reactor
| Autor: | Viviane Gomes Bonifácio, Alexandro Alves Madi, Willian Toito Suarez, Orlando Fatibello-Filho |
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| Rok vydání: | 2009 |
| Předmět: |
Detection limit
Chromatography medicine.diagnostic_test Chemistry Magnesium Biochemistry (medical) Clinical Biochemistry chemistry.chemical_element Captopril Biochemistry Analytical Chemistry Microcrystalline cellulose chemistry.chemical_compound Stearate Spectrophotometry Electrochemistry medicine Ferric Magnesium stearate Spectroscopy medicine.drug |
| Zdroj: | Analytical Letters. 42:973-988 |
| ISSN: | 1532-236X 0003-2719 |
| DOI: | 10.1080/00032710902722095 |
| Popis: | A novel, simple, and rapid flow-injection method for the spectrophotometric determination of captopril in pharmaceutical products, using a solid-phase reactor with silver chloranilate (Ag2C6Cl2O4) immobilized in a polyester resin, is presented. This method explored the formation of an insoluble salt between Ag(I) and captopril in the solid-phase reactor, releasing chloranilate anion ( ). Then, this anion reacted with ferric ions to produce a complex, , which was monitored spectrophotometrically at 528 nm. The analytical curve was linear in the captopril concentration range from 1.0 × 10−5 to 5.0 × 10−4 mol l−1 with a detection limit of 8.0 × 10−6 mol l−1. The relative standard deviation (RSD) was 0.35% (n = 10) for a solution of 3.0 × 10−4 mol l−1 captopril solution, and an analytical frequency of 70 h−1 was obtained. The effects of excipients frequently found with captopril in pharmaceutical formulations, such as lactose, microcrystalline cellulose, starch, and magnesium stearate, were evaluated... |
| Databáze: | OpenAIRE |
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