Change in National Dosing Advice of Nitroprusside After Potentially Fatal Cyanide Intoxication
| Autor: | Guido Bothof, Esther S. Veldhoen, Koen P. van Rhee, Erik Koomen |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Drug
medicine.medical_specialty medicine.drug_class business.industry Cyanide media_common.quotation_subject 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine chemistry medicine 030212 general & internal medicine Dosing Sodium nitroprusside Formulary Complication Antihypertensive drug business Intensive care medicine 030217 neurology & neurosurgery Severe complication media_common medicine.drug |
| Zdroj: | SN Comprehensive Clinical Medicine. 2:522-525 |
| ISSN: | 2523-8973 |
| DOI: | 10.1007/s42399-020-00261-9 |
| Popis: | The aim of this brief communication is to provide a short overview of cyanide intoxication following infusion of sodium nitroprusside (SNP). SNP is a fast-acting antihypertensive drug frequently used in of hypertensive emergencies. Although SNP is widely known as a safe to use drug, it can cause a potentially lethal cyanide intoxication. The difficulty to diagnose cyanide intoxication and pharmacological principles will be discussed. Hereby, we like to regain attention for this severe complication. As a result of our experience, the Dutch national paediatric drug formulary has been updated with additional warnings and recommendations. Cyanide intoxication due to sodium nitroprusside is a severe and difficult to recognize complication with potentially lethal outcome. Clinicians prescribing sodium nitroprusside should always be aware of its toxic effects. |
| Databáze: | OpenAIRE |
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