| Autor: |
N. K. Kalyan, R Rappaport, W.T Hum, Shaw Guang Lee, P. P. Hung, N Hetzel, K.P. Fu |
| Rok vydání: |
1988 |
| Předmět: |
|
| Zdroj: |
Thrombosis Research. 50:33-41 |
| ISSN: |
0049-3848 |
| DOI: |
10.1016/0049-3848(88)90172-7 |
| Popis: |
The pharmacokinetic characteristics of Δ2–89 tPA, characterized by the deletion of the first 89 amino acids at the NH2-terminus of tPA, were evaluated and compared to those of recombinant tPA (rtPA). When they were administered intravenously to mice, a biexponential disposition curve was observed for both tPAs. The plasma half-lives of γ1 and γ2 phases of Δ2–89 tPA were 15 minutes and 180 minutes which are significantly higher than those of rtPA. A zymogram of mouse plasma taken at various time intervals showed that Δ2–89 tPA retained fibrinolytic activity up to 30 minutes, whereas rtPA could be detected only up to 5 minutes after injection. Autoradiography revealed that most of 125I-Δ2–89 tPA was associated with plasma protein complex. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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