1H NMR Determination of Incorporated Porphyrin Location in Lipid Membranes of Liposomes
| Autor: | Atsushi Ikeda, Kouta Sugikawa, Yuki Tsuchiya, Banri Horiguchi, Kenji Komaguchi, Toshimi Nakaya |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Liposome
010405 organic chemistry General Chemistry 010402 general chemistry Resonance (chemistry) 01 natural sciences Porphyrin 0104 chemical sciences chemistry.chemical_compound Electron transfer Membrane chemistry Pyridine Polymer chemistry polycyclic compounds Proton NMR heterocyclic compounds lipids (amino acids peptides and proteins) Pyridinium |
| Zdroj: | Bulletin of the Chemical Society of Japan. 91:1337-1342 |
| ISSN: | 1348-0634 0009-2673 |
| Popis: | Lipid-membrane-incorporated symmetrical and unsymmetrical porphyrins were prepared with relatively high concentrations via exchange from cyclodextrins to liposomes. We determined the location of these porphyrins in the lipid membranes from chemical shift changes of the lipid signals in the 1H NMR spectra. Symmetrical tetraphenyl porphyrin accumulates in the hydrophobic core of the lipid membranes. In contrast, several unsymmetrical porphyrins with more polar group(s), such as pyridine and pyridinium moieties, are located close to the liposome surface. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|