Measurement of natural killer cell cytotoxicity by area under a cytotoxic curve

Autor:	P.T. Dawes, Shadforth Mf, T. P. Sheeran, M. Collins, F.R. Jackson
Rok vydání:	1988
Předmět:	Lymphokine-activated killer cell Immunology Cell Biology medicine.disease Natural killer cell medicine.anatomical_structure Computer analysis Lytic cycle Rheumatoid arthritis medicine Cancer research Immunology and Allergy Cytotoxic T cell Cytotoxicity
Zdroj:	Journal of Immunological Methods. 115:95-98
ISSN:	0022-1759
DOI:	10.1016/0022-1759(88)90314-6
Popis:	Calculation of the area under a curve derived from a 51 Cr cellular release assay gives a reproducible expression of cellular cytoxicity and correlate s well with results at fixed lymphocyte-to-target cell ratios and with lytic units at 20% and 30% cytotoxicity. This method is suitable for quantifying the low cytotoxicity seen in rheumatoid arthritis. The area under the cellular cytotoxic curve may be calculated using a simple mathematical formula or by computer analysis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::60d0217e7e9f29028da075f15de46e63 https://doi.org/10.1016/0022-1759(88)90314-6 Zobrazit plný text záznamu