Activation du complément au cours de la circulation extra-corporelle. Un modèle pour comprendre l'œdème pulmonaire lésionnel
| Autor: | P. Commin, A. Piwnica, D. Bousseau, O. Meyer, E. Echter |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
medicine.medical_specialty
Lung business.industry Extracorporeal circulation Gastroenterology Leukostasis Pulmonary edema medicine.disease Hypoxemia law.invention Complement system medicine.anatomical_structure law Internal medicine Edema Internal Medicine Cardiology medicine Cardiopulmonary bypass medicine.symptom business |
| Zdroj: | La Revue de Médecine Interne. 5:21-27 |
| ISSN: | 0248-8663 |
| Popis: | The complement system (CH50, C3, C4, C3 PA) was monitored during extra-corporeal circulation in 10 patients with ischemic-heart disease. Mean concentrations of CH50, C3, C4, and C3 PA significantly decreased as early as 5 minutes after initiation of the extra-corporeal circulation and decrement remain steady all over the surgical procedure. Transient neutropenia occurred early during the procedure. A significant hypoxemia was present only 24 hours after surgery. We suggest that a complement mediated leukostasis might occur with sequestration in the lungs and contribute to endothelial cell damage with pulmonary edema known as the "post-pump syndrome". |
| Databáze: | OpenAIRE |
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