Effects of coffee and caffeine on bladder dysfunction in streptozotocin-induced diabetic rats1
Autor: | Ze-yu Sun, Xing-rong Li, Chao-ran Yi, Xiang-lei Deng, Zhong-qing Wei, Cheng-gong Tian |
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Rok vydání: | 2006 |
Předmět: |
medicine.medical_specialty
Urinary system medicine.medical_treatment media_common.quotation_subject Intraperitoneal injection urologic and male genital diseases Urination chemistry.chemical_compound Internal medicine Diabetes mellitus medicine Pharmacology (medical) media_common Pharmacology Urinary bladder business.industry General Medicine medicine.disease Streptozotocin female genital diseases and pregnancy complications Surgery medicine.anatomical_structure Endocrinology chemistry business Caffeine Acetylcholine medicine.drug |
Zdroj: | Acta Pharmacologica Sinica. 27:1037-1043 |
ISSN: | 1745-7254 1671-4083 |
Popis: | Aim: To explore the effects and mechanisms of caffeine and coffee on bladder dysfunction in streptozotocin-induced diabetic rats. Methods: Sprague-Dawley male rats were divided randomly into 4 groups: control, diabetes mellitus (DM), DM with coffee treatment, and DM with caffeine treatment. The diabetic rat was induced by intraperitoneal injection of streptozotocin (60 mg/kg). After 7 weeks of treatment with coffee and caffeine, cystometrogram, contractile responses to electrical field stimulation (EFS) and acetylcholine (ACh), and cyclic AMP (cAMP) concentration of the bladder body and base were measured. Results: The bladder weight, volume threshold for micturition and post-void residual volume (PVR) in the diabetic rats were significantly higher compared to those in the control animals. Coffee or caffeine treatment significantly reduced the bladder weight, bladder capacity and PVR in the diabetic rats. DM caused significant decreases in cAMP concentration of the bladder and coffee and caffeine caused upregulation of c AMP content in the diabetic bladder. In addition, coffee and caffeine tended to normalize the altered detrusor contractile responses to EFS and ACh in the diabetic rats. Conclusion: These results indicate that caffeine and coffee may have beneficial effects on bladder dysfunction in the early stage of diabetes by increasing cAMP content in the lower urinary tract, recovering the micturition reflex and improving the detrusor contractility. |
Databáze: | OpenAIRE |
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