Association of MRI Measurements with Cognitive Outcomes After STN-DBS in Parkinson's Disease

Autor:	Stefan Sillau, John A. Thompson, Laura J. Weinkle, Brian D. Hoyt, Olga Klepitskaya, Jody Tanabe, Justin M. Honce
Rok vydání:	2018
Předmět:	0301 basic medicine medicine.medical_specialty Parkinson's disease Disease Audiology Lesion 03 medical and health sciences 0302 clinical medicine medicine Verbal fluency test Cognitive decline business.industry Neuropsychology Retrospective cohort study Cognition medicine.disease nervous system diseases surgical procedures operative 030104 developmental biology nervous system Neurology Neurology (clinical) medicine.symptom business therapeutics 030217 neurology & neurosurgery
Zdroj:	Movement Disorders Clinical Practice. 5:417-426
ISSN:	2330-1619
Popis:	Objectives Subthalamic nucleus deep brain stimulation (STN-DBS) is an effective treatment for improving the motor symptoms of Parkinson's disease (PD). Overall, cognitive function remains stable after STN-DBS in most patients. However, cognitive decline, specifically in the verbal fluency domain, is seen in a subset of STN-DBS patients. Currently, predictors of cognitive decline in PD patients treated with STN-DBS are not well known. Thus, identification of presurgical predictors might provide an important clinical tool for better risk-to-benefit assessment. This study explores whether whole brain white matter lesion (WML) volume, or hippocampal and forebrain volumes, measured quantitatively on MRI, are associated with cognitive changes following STN-DBS in PD patients. Methods We conducted a retrospective study using presurgical, and ≥ 6-month postsurgical neuropsychological (NP) evaluation scores from 43 PD patients with STN-DBS. Mean pre/post NP test scores for measures of executive function, attention, verbal fluency, memory, and visuospatial function were analyzed and correlated with WML volume, and brain volumetric data. Results Although cognitive measures of verbal fluency, executive function, attention, memory, and visuospatial function showed declines following STN-DBS, we observed limited evidence that white matter lesion burden or cortical atrophy contributed to cognitive change following STN-DBS. Conclusions These results suggest that post-STN-DBS cognitive changes may be unrelated to presurgical WML burden and presence of cortical atrophy.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::60b766b477cc09f3c31267f8c2a90694 https://doi.org/10.1002/mdc3.12643 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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