Synthesis of Tamibarotene via Ullmann-Type Coupling

Autor:	Guoliang Chen, Xue-jun Qiao, Changshun Bao, Yi Lu, Xuefei Bao, Xuan Zhao, Yuting Liu
Rok vydání:	2017
Předmět:	Coupling chemistry.chemical_compound Materials science chemistry 010405 organic chemistry Yield (chemistry) Organic Chemistry Tamibarotene Physical and Theoretical Chemistry 010402 general chemistry 01 natural sciences Combinatorial chemistry 0104 chemical sciences
Zdroj:	Organic Process Research & Development. 21:748-753
ISSN:	1520-586X 1083-6160
DOI:	10.1021/acs.oprd.7b00089
Popis:	An effective process was developed for the preparation of tamibarotene via an Ullmann-type coupling in a nonpressurized l-proline/DMSO system. Notable features were the telescoping of reactions, avoiding environmentally hazardous materials, and an acceptable overall yield. The safe scalable process was validated on a 1 kg scale.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::60b4455cd6c8e062ec5214776075bdf3 https://doi.org/10.1021/acs.oprd.7b00089 Zobrazit plný text záznamu