DNA-Interaction and nuclease activity of porphyrin-hydroxamic acid derivatives in the presence of lanthanides

Autor:	Martine Perrée-Fauvet, Kosmas Kefokeris, Nikos Manoussakis, Leonidas Gryllos, Marie-Cecile G. Chalbot, Athanassios G. Coutsolelos, Catherine Verchère-Béaur
Rok vydání:	2011
Předmět:	Lanthanide Nuclease Hydroxamic acid biology General Chemistry Porphyrin Medicinal chemistry Adduct chemistry.chemical_compound chemistry biology.protein Organic chemistry Phenyl group Pyridinium Bond cleavage
Zdroj:	Journal of Porphyrins and Phthalocyanines. 15:704-717
ISSN:	1099-1409 1088-4246
Popis:	The DNA-binding modes and nuclease activity of methylpyridiniumyl/phenyl-hydroxamic acid porphyrin adducts (PHAs) have been studied. These compounds are derived from the tetracationic meso-tetrakis(N-methyl-4-pyridiniumyl)porphyrin (H2TMPyP-4) by replacing one or two pyridinium rings by a phenyl group. A hydroxamic acid function was connected by a polymethylenic chain of 3 to 5 carbon atoms to the meta or para position of the phenyl group. Different DNA-interaction modes were observed depending on the number of charges and hydroxamic acid functions. The nuclease activity in the presence of lanthanides was shown to be depending on the 1/r0 ratio and the nature of the lanthanide ion, and the optimum conditions are depicted after a systematic study.
Databáze:	OpenAIRE
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