Antineutrophil-Cytoplasmic-Autoantibodies in Poststreptococcal Nephritis
| Autor: | Arturo Arriagada, Italo Caorsi, Alvaro Castillo, Sergio Mezzano, Leopoldo Ardiles, Graciela Valderrama, F Olavarria |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Pathology
medicine.medical_specialty Creatinine biology business.industry Autoantibody urologic and male genital diseases medicine.disease respiratory tract diseases chemistry.chemical_compound chemistry immune system diseases Proteinase 3 Cytoplasm Myeloperoxidase biology.protein medicine Rapidly progressive glomerulonephritis cardiovascular diseases skin and connective tissue diseases business Nephritis Systemic vasculitis |
| Zdroj: | Advances in Experimental Medicine and Biology ISBN: 9781475791846 |
| DOI: | 10.1007/978-1-4757-9182-2_80 |
| Popis: | Sera from 210 patients with APSGN, were tested for the presence of ANCA (IgG-isotype). Indirect immunofluorescence (IF) on ethanol fixed human PMNs was used, and for those positive sera, ELISA kits for PR3 (Proteinase 3) and MPO (Myeloperoxidase) was performed. ANCA were detected in 9% (18 out of 210 cases) in a predominantly diffuse cytoplasmic staining pattern in 14 cases (77%), and in a perinuclear pattern in the remaining 4 cases (22%). Anti-MPO was found in 4 cases (C-ANCA 3; P-ANCA 1) and anti-PR3 was always negative. The presence of ANCA was significantly associated with a more severe glomerular disease as assessed by the serum creatinine value and the crescents formation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|