Drug Synthesis and Analysis on a Dime: A Capstone Medicinal Chemistry Experience for the Undergraduate Biochemistry Laboratory
Autor: | Pamela S. Mertz, Amanda J. Schech, Kelly Y. Neiles, Craig N. Streu, Randall D. Reif |
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Rok vydání: | 2016 |
Předmět: | |
Zdroj: | Journal of Chemical Education. 93:2084-2088 |
ISSN: | 1938-1328 0021-9584 |
DOI: | 10.1021/acs.jchemed.6b00048 |
Popis: | Integrative, research-based experiences have shown tremendous potential as effective pedagogical approaches. Pharmaceutical development is an exciting field that draws heavily on organic chemistry and biochemistry techniques. A capstone drug synthesis/analysis laboratory is described where biochemistry students synthesize azo-stilbenoid compounds and test the biological activity of those compounds as well as a known inhibitor on mushroom tyrosinase using UV/vis-based kinetic assays. In this paper, three such successful azo-stilbenoid inhibitors of tyrosinase, representative student generated data, technical aspects of the experiments, and an interpretation of student feedback on the project as a whole are presented. |
Databáze: | OpenAIRE |
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