Drug Synthesis and Analysis on a Dime: A Capstone Medicinal Chemistry Experience for the Undergraduate Biochemistry Laboratory

Autor:	Pamela S. Mertz, Amanda J. Schech, Kelly Y. Neiles, Craig N. Streu, Randall D. Reif
Rok vydání:	2016
Předmět:	0301 basic medicine Science instruction Chemistry 05 social sciences 050301 education General Chemistry Education 03 medical and health sciences 030104 developmental biology Drug synthesis Biochemistry Capstone Mushroom tyrosinase 0503 education
Zdroj:	Journal of Chemical Education. 93:2084-2088
ISSN:	1938-1328 0021-9584
Popis:	Integrative, research-based experiences have shown tremendous potential as effective pedagogical approaches. Pharmaceutical development is an exciting field that draws heavily on organic chemistry and biochemistry techniques. A capstone drug synthesis/analysis laboratory is described where biochemistry students synthesize azo-stilbenoid compounds and test the biological activity of those compounds as well as a known inhibitor on mushroom tyrosinase using UV/vis-based kinetic assays. In this paper, three such successful azo-stilbenoid inhibitors of tyrosinase, representative student generated data, technical aspects of the experiments, and an interpretation of student feedback on the project as a whole are presented.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::60b1ab645b2cf95f67d43f389df6cc77 https://doi.org/10.1021/acs.jchemed.6b00048 Zobrazit plný text záznamu