Drug Synthesis and Analysis on a Dime: A Capstone Medicinal Chemistry Experience for the Undergraduate Biochemistry Laboratory

Autor: Pamela S. Mertz, Amanda J. Schech, Kelly Y. Neiles, Craig N. Streu, Randall D. Reif
Rok vydání: 2016
Předmět:
Zdroj: Journal of Chemical Education. 93:2084-2088
ISSN: 1938-1328
0021-9584
DOI: 10.1021/acs.jchemed.6b00048
Popis: Integrative, research-based experiences have shown tremendous potential as effective pedagogical approaches. Pharmaceutical development is an exciting field that draws heavily on organic chemistry and biochemistry techniques. A capstone drug synthesis/analysis laboratory is described where biochemistry students synthesize azo-stilbenoid compounds and test the biological activity of those compounds as well as a known inhibitor on mushroom tyrosinase using UV/vis-based kinetic assays. In this paper, three such successful azo-stilbenoid inhibitors of tyrosinase, representative student generated data, technical aspects of the experiments, and an interpretation of student feedback on the project as a whole are presented.
Databáze: OpenAIRE