| Autor: |
Michele Cortellaro, G. Moreo, Elisabetta Cofrancesco, M. Salvatore, C. Boschetti, E Poliani |
| Rok vydání: |
1987 |
| Předmět: |
|
| Zdroj: |
XIth International Congress on Thrombosis and Haemostasis. |
| ISSN: |
2567-689X |
| DOI: |
10.1055/s-0038-1643205 |
| Popis: |
α2AP (Coatest Antiplasmin Kit, Ortho Diagnostic Systems), antithrombin III (Atlll, Coatest Antithrombin Kit, Ortho Diagnostic Systems) and plasminogen (S2251) were assayed in 21 patients with acute nonlymphoblastic leukaemia (ANLL: 5M2 5M4 5M5) before and after chemotherapy and during bone marrow cellularity recovery. The aim of the work was to investigated disturbances of coagulation and fibrinolysis with special reference to proteases inhibitors and to evaluate the prognostic value of changes in these parameters in ANLL patients. Low α2AP levels were observed in the initial phase of the disease: Ul.5 ± 2k.79 SD in 10 DIC patients versus 6U.10 !± 20.70 SD in patients without DIC (p < 0.05). α2AP normalized only in the 11 patients who achieved haematological remission (71.63 ± 13.13 SD) and remained low in those who did not respond to chemotherapy (6l.88 ± 17.86 SD, p < 0.01). No significant modification of Atlll and plasminogen levels were observed during the course of the illness.It may be postulated that proteolytic cleavage of α2AP by granulocyte proteases contributes to the low levels of the inhibitor in ANLL, and suggested that α2AP may represent a marker of leu-kaemic disease activity. In fact the mean α2AP level of all patients at diagnosis plus those who did not respond to chemotherapy was significantly lower than that of patients in haematological remission (55.93 ± 23.13 versus 71.63 ± 13.13, p < 0.05). |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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