Autor: |
Jinxin Wang, Qing Long Guo, Hongyan Li, Nian Guang Li, Xue Feng Huang, Yan Li, Xiao Guang Chen, Qi Dong You |
Rok vydání: |
2007 |
Předmět: |
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Zdroj: |
Chinese Chemical Letters. 18:659-662 |
ISSN: |
1001-8417 |
Popis: |
Through simplifying the complicated skeleton of the natural product gambogic acid, two series derivatives of chromone and xanthone were synthesized and examined for their antitumor activities against several cancer cells in vitro by MTT method. The results showed that appropriate introduction of prenyl group to the small molecular compounds could elevate their antitumor activities. The structure-activities relationship of synthesized compounds certified that the bridgecore in gambogic acid was very important for keeping its antitumor activities. |
Databáze: |
OpenAIRE |
Externí odkaz: |
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