Synthesis and antitumor activities of structure-related small molecular compounds of gambogic acid

Autor:	Jinxin Wang, Qing Long Guo, Hongyan Li, Nian Guang Li, Xue Feng Huang, Yan Li, Xiao Guang Chen, Qi Dong You
Rok vydání:	2007
Předmět:	chemistry.chemical_compound Natural product chemistry Prenylation Stereochemistry Cancer cell Chromone Xanthone Mtt method Gambogic acid General Chemistry In vitro
Zdroj:	Chinese Chemical Letters. 18:659-662
ISSN:	1001-8417
Popis:	Through simplifying the complicated skeleton of the natural product gambogic acid, two series derivatives of chromone and xanthone were synthesized and examined for their antitumor activities against several cancer cells in vitro by MTT method. The results showed that appropriate introduction of prenyl group to the small molecular compounds could elevate their antitumor activities. The structure-activities relationship of synthesized compounds certified that the bridgecore in gambogic acid was very important for keeping its antitumor activities.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::60aee1689ac5771188a51102a47950d0 https://doi.org/10.1016/j.cclet.2007.04.010 Zobrazit plný text záznamu Full Text from ScienceDirect