Smoking is associated with hypermethylation of theAPC1A promoter in colorectal cancer: the ColoCare Study
| Autor: | Melanie Boerries, Hermann Brenner, Dominique Scherer, Stephanie Skender, Petra Schrotz-King, Alexis Ulrich, Peter Schirmacher, Martin F. Schneider, Lin Zielske, Nina Habermann, Timothy M. Barrow, Clare Abbenhardt-Martin, Hagen Klett, Jürgen Böhm, Cornelia M. Ulrich, Biljana Gigic, Karin B. Michels, Esther Herpel, Reka Toth, Hauke Busch |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty business.industry Colorectal cancer Smoking Tobacco Disease medicine.disease Pathology and Forensic Medicine 03 medical and health sciences 030104 developmental biology 0302 clinical medicine CpG site 030220 oncology & carcinogenesis Internal medicine DNA methylation medicine Epigenetics Risk factor business Biomedical sciences |
| Zdroj: | The Journal of Pathology. 243:366-375 |
| ISSN: | 0022-3417 |
| Popis: | Smoking tobacco is a known risk factor for the development of colorectal cancer, and for mortality associated with the disease. Smoking has been reported to be associated with changes in DNA methylation in blood and in lung tumour tissues, although there has been scant investigation of how epigenetic factors may be implicated in the increased risk of developing colorectal cancer. To identify epigenetic changes associated with smoking behaviours, we performed epigenome-wide analysis of DNA methylation in colorectal tumours from 36 never smokers, 47 former smokers and 13 active smokers, and adjacent mucosa from 49 never smokers, 64 former smokers and 18 active smokers. Our analyses identified 15 CpG sites within the APC 1A promoter that were significantly hypermethylated and 14 CpG loci within the NFATC1 gene body that were significantly hypomethylated (pLIS |
| Databáze: | OpenAIRE |
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