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The goal of this research was to produce a proliposomal formulation of ketoconazole, an antifungal medication, to treat dandruff. Thin-film hydration was used to create proliposomes with various mannitol, phospholipid, and cholesterol contents (vacuum rotatory evaporator). Based on medication content, entrapment efficiency, and average size, prepared proliposomal formulations were optimised. As part of the carbopol gel formulation, the newly created proliposomal formulation was evaluated for its rheological characteristics and in vitro drug release tests. The concentrations of phospholipids and cholesterol in formulations were shown to be critical to their optimal entrapment efficiency. Stability of the carbopol-coated proliposome formulation for topical medication administration was determined by rheological experiments. Proliposomal gel formulations, as compared to pure medicines, show greater skin penetration and sustained release in vitro. |
