Synthesis of peptides with α,β-dehydroamino acids, VI. Synthesis ofN-benzyloxycarbonyl andN-trifluoroacetyl dipeptides of α,β-dehydro-butyrine, -valine, -leucine, and -isoleucine

Autor:	Zbigniew Kubica, Leszek Smelka, Barbara Rzeszotarska, Pietrzyński G
Rok vydání:	1988
Předmět:	Chemistry Valine Stereochemistry Organic Chemistry Condensation Physical and Theoretical Chemistry Leucine Isoleucine Catalysis
Zdroj:	Liebigs Annalen der Chemie. 1988:485-486
ISSN:	1099-0690 0170-2041
DOI:	10.1002/jlac.198819880520
Popis:	Condensation of Z- and TFA-amino acid amides with 2-oxo-acids, namely butanoic, 3-methylbutanoic, 4-methylpentanoic, and (3RS)-3-methylpentanoic acid, yields (in the presence of p-toluenesulfonic acid as a catalyst) Z- and TFA-dipeptides with C-terminal ΔAbu2) (1–4), ΔVal (5–8), ΔLeu (9–11), and ΔIle (12–15) (Table 1).
Databáze:	OpenAIRE
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