An Insilico pharmacological evaluation of saraswatharishtam for alzheimer's disease - an ayurvedic formulation

Autor:	N.J. Merlin, TM Aparna, Shaiju S Dharan
Rok vydání:	2020
Předmět:	chemistry.chemical_compound Nicotinic acetylcholine receptor chemistry Docking (molecular) Gingerol Tonic (music) Pharmacology (medical) Pharmacology Pharmacology Toxicology and Pharmaceutics (miscellaneous) ADME
Zdroj:	Research Journal of Pharmacy and Technology. 13:4172
ISSN:	0974-360X 0974-3618
Popis:	Saraswatharishtam is a standard Ayurvedic tonic for treating mental disorders in general. The present study deals with the insilico ADME evaluation and molecular docking studies of phytoconstituents present in Saraswatharishtam using SWISS ADMET and docking software such as Pyrex, pyMOL and Open babel. The results of the study shows that Baccosides, Kaemferol, Puerarinand Gingerol shows better docking score and hydrogen bond interaction with its potential Nicotinic Acetylcholine Receptor(1HOY) which may be responsible for neuroprotective activity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::6086753fede5ce22b21396ca8b4d37d3 https://doi.org/10.5958/0974-360x.2020.00736.2 Zobrazit plný text záznamu