Endogenous thrombopoietin serum levels during multicycle chemotherapy
| Autor: | Christoph Engel, Horst Franke, Stephan Schmitz, Markus Loeffler |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
endocrine system
medicine.medical_specialty Chemotherapy business.industry medicine.medical_treatment Response characteristics food and beverages hemic and immune systems Endogeny Hematology medicine.disease Treatment period Lymphoma fluids and secretions medicine.anatomical_structure Endocrinology Megakaryocyte Internal medicine embryonic structures Immunology medicine Platelet business Thrombopoietin |
| Zdroj: | British Journal of Haematology. 105:832-838 |
| ISSN: | 0007-1048 |
| DOI: | 10.1046/j.1365-2141.1999.01459.x |
| Popis: | Little is known about the behaviour of endogenous thrombopoietin (TPO) serum levels during rapid sequences of dose-intensified chemotherapy. To characterize the relationship between TPO levels and platelet counts in this setting we serially measured both parameters over the entire treatment period of patients receiving multicycle polychemotherapy. We found TPO and platelet responses to be generally antagonistic through all cycles. However, a cross-correlation analysis indicated that TPO responses preceded platelet responses by approximately one day in all patients. The cumulative severity of thrombocytopenia observed over successive cycles was accompanied by an increasing TPO response which tended to grow overproportionally in relation to the degree of peripheral thrombocytopenia. These findings are consistent with a model suggesting that both platelet and megakaryocyte mass contribute to a receptor-dependent consumption process regulating the endogenous TPO level. In order to develop optimal schedules for exogenous TPO administration it might be important to consider endogenous TPO response characteristics. |
| Databáze: | OpenAIRE |
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