Citrus junos Fruit Extract Facilitates Anti-Adipogenic Activity of Garcinia cambogia Extract in 3T3-L1 Adipocytes by Reducing Oxidative Stress
Autor: | Hyun Jung Kim, Sung-Hwa Oh, Min-Ho Oak, Eunyoung Yi, Deepak Adhikari, Kushal Sharma |
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Rok vydání: | 2019 |
Předmět: |
chemistry.chemical_classification
Reactive oxygen species Materials science Garcinia cambogia Biomedical Engineering Adipose tissue Bioengineering 3T3-L1 02 engineering and technology General Chemistry 021001 nanoscience & nanotechnology Condensed Matter Physics medicine.disease_cause Citrus junos food.food Cell biology chemistry.chemical_compound food chemistry Adipogenesis Adipocyte medicine General Materials Science 0210 nano-technology Oxidative stress |
Zdroj: | Journal of Nanoscience and Nanotechnology. 19:915-921 |
ISSN: | 1533-4880 |
Popis: | Obesity is a metabolic disorder associated with chronic oxidative stress and inflammation. Recruitment of inflammatory cells to adipose tissue and subsequent production of a large amount of reactive oxygen species (ROS) facilitates adipocyte differentiation and promotes lipid accumulation. The removal of ROS with anti-oxidants appeared an effective strategy against lipid accumulation. Here, we chose Citrus junos, a good dietary source of anti-oxidants and tested the anti-adipogenic potential of Citrus junos extract (CE). CE effectively suppressed the ROS production and lipid accumulation in H₂O₂-stimulated 3T3-L1 cells. CE also inhibited the expression of CEBP-α and PPAR-γ, the transcription regulators of adipocyte differentiation. These data suggest that CE might suppress the adipocyte differentiation through ROS scavenging action. Also, CE and Garcinia cambogia extract (GE) appeared act additively in reducing ROS and in inhibiting lipid accumulation. It implied a potential usefulness of this combination in the management of obesity related disorders. |
Databáze: | OpenAIRE |
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