Steroid-regulated morphological plasticity in a set of identified peptidergic neurons in the moth Manduca sexta
| Autor: | Nathan J. Tublitz, Hillary F. McGraw, Kevin R. S. Prier, Jesse C. Wiley |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
medicine.medical_specialty
Physiology medicine.medical_treatment Neuropeptide Aquatic Science chemistry.chemical_compound Internal medicine Neuropil medicine Neurotransmitter Molecular Biology Ecology Evolution Behavior and Systematics Bursicon biology fungi biology.organism_classification Phenotype Cell biology Steroid hormone medicine.anatomical_structure Endocrinology chemistry Manduca sexta Insect Science Animal Science and Zoology sense organs Neurosecretion |
| Zdroj: | Journal of Experimental Biology. 201:2981-2992 |
| ISSN: | 1477-9145 0022-0949 |
| DOI: | 10.1242/jeb.201.21.2981 |
| Popis: | The lateral neurosecretory cells (LNCs) in the tobacco hornworm Manduca sexta undergo a switch in neurotransmitter phenotype during pupation. Concurrent with this change in function, the LNCs undergo a major morphological reorganization. This study characterizes the morphological change and its underlying cause. In the larva, the LNC has a very compact dendritic arborization in a small volume of neuropil ipsilateral to the cell soma. In the adult moth, the LNC arborization extends through a much larger volume of neuropil, including the contralateral side of the ganglion. Using both in vivo manipulations and a single-cell culture system, we show that this change in morphology is probably triggered by two pulses of the steroid hormone 20-hydroxyecdysone (20-HE): a small commitment peak and a larger prepupal pulse. These are the same two pulses of 20-HE as those previously shown jointly to cause the change in transmitter phenotype. This work, in conjunction with a previous study on the transmitter switch, documents the orchestration of major morphological and biochemical changes in a set of identified neurons by a single hormone. |
| Databáze: | OpenAIRE |
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