| Autor: |
Sylvain Harquel, Andéol Cadic-Melchior, Takuya Morishita, Lisa Fleury, Martino Ceroni, Pauline Menoud, Julia Brügger, Elena Beanato, Nathalie Meyer, Giorgia G. Evangelista, Philip Egger, Dimitri Van de Ville, Olaf Blanke, Silvestro Micera, Bertrand Léger, Jan Adolphsen, Caroline Jagella, Andreas Mühl, Christophe Constantin, Vincent Alvarez, Philippe Vuadens, Jean-Luc Turlan, Diego San Millán, Christophe Bonvin, Philipp J. Koch, Maximilian J. Wessel, Friedhelm C. Hummel |
| Rok vydání: |
2023 |
| Popis: |
Stroke is the leading cause of long-term disability, making the search for successful rehabilitation treatment one of the most important public health issues. A better understanding of the neural mechanisms underlying impairment and recovery and the development of associated markers is critical for tailoring treatments to each individual patient with the ultimate goal of maximizing therapeutic outcomes. Here, we used a novel and powerful method consisting of combined transcranial magnetic stimulation (TMS) and multichannel electroencephalography (EEG) to analyze TMS-induced brain oscillations in a large cohort of 60 stroke patients from the acute to the early-chronic phase after a stroke. A data-driven parallel factor analysis (PARAFAC) approach to tensor decomposition allowed to detect brain oscillatory modes specifically centered on the θ, α and β frequency bands. In the acute stage, patients presented a general slowdown of these oscillatory modes, highlighting stroke-induced perturbations within thalamocortical processing. Furthermore, low-frequency modes evolved across stroke stages, according to the extent of motor recovery, associated with changes in GABAergic intracortical inhibition. Overall, these longitudinal changes provide novel insights into the ongoing functional reorganization of brain networks after a stroke and the underlying mechanisms. Notably, we propose that the observed α-mode decrease corresponds to a beneficial disinhibition phase between the subacute and early-chronic stages that fosters structural and functional plasticity and facilitates recovery. Monitoring this phenomenon at the individual patient level will provide critical information for phenotyping patients, developing electrophysiological biomarkers and refining therapies based on personalized excitatory/inhibitory neuromodulation using noninvasive or invasive brain stimulation techniques. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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